Zeynep Yesim Kucuk

Zeynep Yesim Kucuk


Dr. Zeynep Yesim Kucuk joined Otolaryngology Associates in February 2021. She is board certified in Pediatrics and Pediatric and Adult Allergy & Immunology.

Dr. Kucuk received her MD degree from Istanbul University, Istanbul School of Medicine, Turkey. She completed a 5-year residency program in Pediatrics before she moved to the U.S. in 2002. She earned her American Pediatrics degree at the Long Island Jewish Hospital/North Shore University, Cohen Children’s Hospital. She completed her Allergy and Immunology fellowship training at Cincinnati Children’s Hospital, University of Cincinnati.

Dr. Kucuk also has expertise in Clinical Immunology, following a Clinical Immunodeficiency Fellowship in the Division of Bone Marrow Transplantation and Immune Deficiency at Cincinnati Children’s Hospital Medical Center, where she subsequently was recruited as a faculty member.

She is a physician-scientist, who has been fortunate to be mentored by many internationally known academicians/scientists, including Drs. Hugh Sampson, Wayne Shreffler, Fred Finkelman and Marc Rothenberg in basic and translational research of food allergy and anaphylaxis; Drs. Jonathan Bernstein and David Bernstein in clinical allergy disorders and asthma; Drs Lisa Filipovich, Stella Davies, Michael Jordan and Jack Bleesing in translational research and clinical outcome studies in immune deficiency disorders and bone marrow transplantation.

She has been an invited speaker at the national and international meetings including American Academy of Allergy, Asthma and Immunology (AAAAI), Clinical Immunology Society (CIS), European Society for Immunodeficiencies (ESID), American Society of Bone Marrow Transplantation (ASBMT), Primary Immune Deficiency Treatment Consortium (PIDTC) among others.

In her free time, she likes choreographic dancing, innovative cooking, and travel for art and history. She is a native Turkish, lives in Mclean with her husband and dog Suzie.

List of Certifications and Affiliations

  • Board certified by American Board of Pediatrics
  • Board certified by American Board of Allergy and Immunology
  • Member of American Academy of Allergy, Asthma and Immunology
  • Member of Clinical Immunology Society
  • Member of European Society for Immunodeficiencies

Selected Publications

Therapeutic Options for CTLA-4 Insufficiency. David Egg1, Zeynep Yesim Kucuk, M.D.16, et al. Accepted, in press, J Allergy Clin Immunol. April, 2021

Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4-insufficient subjects. Charlotte Schwab, Zeynep Yesim Kucuk, et al. J Allergy Clin Immunol. 2018 Dec;142(6):1932-1946. doi: 10.1016/j.jaci.2018.02.055.

Gimap5 is required for GSK3β inactivation thereby facilitating accumulation of transcription factors and limiting DNA damage during T cell proliferation. Andrew Patterson, Zeynep Yesim Kucuk, et al. Nature Communications, 2018, 9:430 DOI:10.1038/s41467-018-02897-7.

IPEX syndrome survivors following different therapeutic strategies: An international multicenter retrospective study. Barzaghi F, Kucuk Z.Y, et al. J Allergy Clin Immunol. 2018 Mar;141(3):1036-1049.e5. doi: 10.1016/j.jaci.2017.10.041. Epub 2017 Dec 11.

Hematopoietic stem cell transplantation in 26 patients hemizygous for hypomorphic IKBKG / NEMO mutations. Charline Miot, Zeynep Yesim Kucuk, et al. Blood. 2017 Sep 21;130(12):1456-1467. doi: 10.1182/blood-2017-03-771600. Epub 2017 Jul 5. PMID: 28679735

Persistent Enteropathy in a Toddler with a Novel FOXP3 Mutation and Normal FOXP3 Protein Expression. Sara Seghezzo MD, Jack JH Bleesing, Zeynep Yesim Kucuk MD. J Pediatr. 2017 Jul;186:183-185. doi: 10.1016/j.jpeds.2017.03.051. Epub 2017 Apr 27. PMID: 28457527

Outcome of Haematopoietic Stem Cell Transplantation for DNA-Double Strand Breakage Repair Disorders: An EBMT/ESID IEWP, SCETIDE and CIBMTR/PIDTC Survey. Slack J, Kucuk ZY, et al. on behalf of the Inborn Errors Working Party of the European Society for Blood and Marrow Transplantation and the European Society for Immunodeficiencies, Stem Cell Transplant for Immunodeficiencies in Europe (SCETIDE), the Center for International Blood and Marrow Transplant Research, and the Primary Immunodeficiency Treatment Consortium. J Allergy Clin Immunol. 2017 Apr 6. pii: S0091-6749(17)30567-5. doi10.1016/j.jaci.2017.02.036.

CTLA-4 Haploinsufficiency in a Patient with Autoimmune Lymphoproliferative Disorder. Zeynep Yesim Kucuk MD, Louis-Marie Charbonnier PhD, et al. J Allergy Clin Immunol. 2017 Mar 30. pii: S0091-6749(17)30508-0. doi: 10.1016/j.jaci.2017.02.032.

The broad clinical spectrum and unexpected features of Activated PI3-kinase Delta Syndrome; large patient cohort study. Tanya Coulter, MRCPI, Zeynep Yesim Kucuk, MD, et al. J Allergy Clin Immunol. 2017 Feb;139(2):597-606.e4. doi: 10.1016/j.jaci.2016.06.021.

CTP synthase 1 Deficiency in Successfully Transplanted Siblings with Combined Immune Deficiency and Chronic Active EBV Infection. Zeynep Yesim Kucuk MD, Kejian Zhang MD, Lisa Filipovich MD, Jack JH Bleesing MD PhD. Journal of Clinical Immunology, 2016 Nov;36(8):750-753.

A challenging undertaking: Stem cell transplantation for immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome. Kucuk ZY, Bleesing JJ, Marsh R, Zhang K, Davies S, Filipovich AH. J Allergy Clin Immunol. 2015 Nov 7. pii: S0091-6749(15)01374-3. doi: 10.1016/j.jaci.2015.09.030.

Activated PI-3-Kinase-C Delta Syndrome (APDS) in a patient with former diagnosis of CVID and lymphoproliferative disease. Kannan JA, Davila-Sandala BJ, Zhang, Filipovich AH, Kucuk ZY. Ann Allergy Asthma Immunol. 2015 Nov;115 (5):452-4

Rapid desensitization of mice with anti-FcRIIb/FcRIII mAb safely prevents IgG-mediated anaphylaxis. Khodoun M., Kucuk Z.Y., et al. J Allergy Clin Immunol. 2013 Dec;132(6):1375-87. doi: 10.1016/j.jaci.2013.09.008. Epub 2013 Oct 18.

Rapid polyclonal desensitization with antibodies to IgE and FcεRIα. Khodoun M., Kucuk Z.Y., et al. J Allergy Clin Immunol. 2013, Jun;131(6):1555-64. doi: 10.1016/j.jaci.2013.02.043. Epub 2013.

Induction and suppression of allergic diarrhea and systemic anaphylaxis in a mouse model of food allergy. Kucuk Z.Y., Strait R.T., et al. J Allergy Clin Immunol. 2012 May;129 (5):1343-8.

The major glycoprotein allergen from Arachis hypogaea, Ara h 1, is a ligand of DC-SIGN and acts as a Th2 adjuvant in vitro. Shreffler, W.G., Castro, R.R., Kucuk, Z.Y., et al. Journal of Immunology. 2006. 177:3677-3685.